It seems that Biden's Middle Eastern policy will be affected by his attitude toward Iran more than anything else. His approach to Tehran seems to be the Archimedean point that will define the depth of Washington's involvement, and inform its relations with regional allies.
An analysis of the statements made by the president-elect and his national security team supports the notion that the incoming administration is interested in returning to the JCPOA while lifting the sanctions, without insisting on negotiations with Tehran to rectify its grievous flaws: the expiration of limitations (starting seven years from now), which could pave the way for Iran to become an internationally legitimized nuclear threshold state; advanced centrifuge R&D that significantly reduces the breakout time Iran requires to produce weapon-grade fissile material; and the lack of authority for the IAEA to monitor the nuclear weapons program.
It seems that the return to the JCPOA is the administration's way of "setting aside" the Iranian issue in order to focus on more urgent matters, such as: addressing domestic socio-economic problems; great power competition, particularly with China; and reinstating America's status globally. Tehran, for its part, is eager to remove the sanctions yoke from around its neck, as they are detrimental to its economy, and has made it clear that it is willing to fully comply with the agreement once more, with no need even for negotiations with the U.S.
Despite what may seem as a zone of possible agreement between Iran and the United States – supported by Europe, Russia, and China – the return to the JCPOA may run into a series of obstacles, and get derailed. Among such hurdles are: an unplanned escalation – for instance, in Iraq; possible disputes over the sequence of steps constituting the return to the JCPOA – will compliance come before or after the lifting of sanctions? – as well as the baseline to which Iran must return in complex issues, such as the know-how accumulated through R&D; internal conflict between the conservatives and Rouhani's government expected to exacerbate as the June elections draw nearer, which could potentially lead to Iran's terms becoming more stringent; the effect of this step on the relations between the Biden administration and Israel or the Arab states, and more.
In light of their complexity, the probes and talks between the U.S., Europe, and Iran could take some time, thereby allowing Israel enough time to make an impact on the Biden administration's stance and planned actions in this matter.